RUKOBIA — A BREAKTHROUGH FIRST-IN-CLASS TREATMENT WITH A NOVEL MOA2
RUKOBIA, as part of an optimised background regimen, is the only therapy developed for people living with MDR HIV-1 clinically proven to offer virologic suppression and CD4+ T-cell recovery over 5 years.2,3
RUKOBIA INCLUDED IN EACS 2023 GUIDELINES
When a 2-3 drugs active regimen cannot be constructed with NRTI, NNRTI, PI/b and INSTI, a drug with a new mechanism of action such as fostemsavir can be selected to obtain such a 2-3 drugs active regimen.5
The many faces of people living with MDR HIV-1
See perspectives from people living with MDR HIV-1
First-in-class attachment inhibitor
Find out what makes RUKOBIA different from other ARV therapies6
Durable 5-year efficacy
Explore the 5-year virologic suppression data for RUKOBIA for people living with MDR HIV-13
Breaking news: 240-week BRIGHTE trial results
Dr. Mills shares an exciting announcement about the BRIGHTE 5-year data for RUKOBIA for people living with MDR HIV-13
ARV=antiretroviral; HIV-1=human immunodeficiency virus type-1; INSTI=integrase strand transfer inhibitor; MDR=multidrug-resistant; MOA=mechanism of action; NRTI=nucleoside reverse transcriptase inhibitor; NNRTI=nonnucleoside reverse transcriptase inhibitor; PI=protease inhibitor.
RUKOBIA, in combination with other antiretrovirals, is indicated for the treatment of adults with multidrug resistant HIV-1 infection for whom it is otherwise not possible to construct a suppressive anti-viral regimen.2
References:
- Ackerman P, Thompson M, Molina JM, et al. Long-term efficacy and safety of fostemsavir among subgroups of heavily treatment-experienced adults with HIV-1. AIDS. 2021;35(7):1061-1072.
- RUKOBIA Summary of Product Characteristics.
- Aberg J, Shepherd B, Wang M, et al. Poster presented at the 24th International AIDS Conference. 29 July – 2 August 2022. Montreal, Canada. EPB160.
- Llibre J, Aberg J, Walmsley S, et al. Poster present at the 19th European AIDS Conference (EAC). 18-21 October 2023. Warsaw, Poland. eP.A.093.
- EACS Guidelines. Version 12.0. October 2023.
- Lataillade M, Lalezari JP, Kozal M, et al. Safety and efficacy of the HIV-1 attachment inhibitor prodrug fostemsavir in heavily treatment-experienced individuals: week 96 results of the phase 3 BRIGHTE study. Lancet HIV. 2020;7(11):740-751.
PM-GBL-FST-WCNT-230008 | January 2025